PMG Pharm® Layla® 12-Herb Joint Soothing Formula
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PMG Pharm® Layla® 12-Herb Joint Soothing Formula
If you’ve already tried glucosamine, chondroitin, MSM, or even multiple joint formulas, yet still find yourself repeatedly dealing with aching, stiffness, and discomfort when climbing stairs, you’ve probably realized something important: joint issues aren’t simply a matter of “whether you’re supplementing enough.” In real life, many joint concerns don’t come from a single injury, but from the gradual accumulation of long-term wear, reduced recovery capacity, and regulatory imbalance.
These changes are commonly seen during life stages associated with hormonal fluctuations or declines in women, and are also present in age-related degenerative changes in older adults, as well as from long-term physical activity, manual labor, or repetitive joint loading. For many middle-aged men, even when overall strength and activity levels remain high, the combination of slower recovery, accumulated stress, and insufficient sleep makes joints more prone to stiffness and discomfort after exercise, prolonged sitting, or periods of intense physical or mental demand. As circulation, lubrication, and the body’s natural repair capacity around the joints gradually decline, movements that once felt effortless may begin to require a moment to “ease into.”
This is exactly where Layla differs most from traditional G + C + M (glucosamine + chondroitin + MSM) formulas. Traditional G + C + M approaches are more focused on “supplying joint building blocks,” assuming discomfort mainly comes from insufficient cartilage nutrition, and therefore relying on long-term, continuous supplementation of structural components. But when the core issue is more about regulatory capacity and how the joint is being used, this approach can leave people feeling like “I’ve taken it for a long time, but the results are limited.”
Layla (labeled as PG201 in clinical research) takes a more holistic approach built on the synergistic action of 12 plant-derived extracts. The focus isn’t “how much you’re adding,” but rather how the joint functions in real daily life. This non-steroidal, plant-based herbal formula supports soft-tissue relaxation, local circulation, and inflammatory balance to help improve joint flexibility and comfort during everyday movements such as walking, standing up, and going up or down stairs. The formula contains no hormones and does not rely on chemical pain-relief ingredients, making it more suitable as a long-term joint support option.
This design logic is also supported by evidence-based research. In a randomized, double-blind, multicenter clinical study published in Journal of Ethnopharmacology , PG201 was studied in people with knee osteoarthritis and directly compared with an established Korean herbal joint product. Across outcomes including pain relief, joint function, and quality of life, it demonstrated consistent and reproducible improvements.
In addition, the safety and efficacy of PG201 were evaluated in a randomized, double-blind, multicenter phase III clinical study published in Rheumatology International , which enrolled patients with symptomatic knee osteoarthritis. The results demonstrated that PG201 was well tolerated and met the pre-specified non-inferiority criteria for pain improvement compared with the conventional comparator.
For those who don’t want to rely on long-term painkillers, and who aren’t satisfied with traditional “take a lot but feel limited” supplement approaches, Layla offers a gentler joint management option that aligns more closely with real-day experience.
*This product is an herbal nutritional support supplement. It contains no hormones and is not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary depending on age, hormonal status, activity load, and lifestyle factors.
Angelica gigas
In traditional Korean herbal systems, Angelica gigas is commonly used to support circulation and ease feelings of tightness. For people who feel discomfort when standing up after long periods of sitting, experience seasonal stiffness, or notice soreness after activity, this herb works more from a “flow and release” perspective, helping restore a smoother joint sensation.
When combined with the other herbs in Layla, it acts as a form of “baseline mobility support”: encouraging surrounding soft tissues to relax more easily and movements to feel more continuous, indirectly supporting comfort and flexibility during walking, stair climbing, and post-exercise recovery.
Chaenomeles Fruit
Traditionally used to help relax tendons and ease stiffness or contractive sensations, Chaenomeles fruit is especially suitable for joints that don’t feel sharply painful, but instead feel “stuck,” tight, or resistant when you start to move. Its focus is on supporting soft-tissue elasticity and smoother range of motion.
For cumulative load caused by long-term exercise, repeated training, or physical labor, Chaenomeles fruit plays the role of “restoring natural movement” within the formula: helping reduce pulling or tight sensations when standing up, squatting, or walking, so joints feel more usable and resilient.
Blue Throatwort
In herbal formulas, blue throatwort is often used to support localized soothing and sensitivity management, making it suitable for people who feel persistent dull discomfort or fullness around the joints. Rather than strong stimulation, it emphasizes a gentle approach that can be maintained long term.
During periods of high stress, slower recovery, or reduced regulatory capacity (such as during hormonal transitions), blue throatwort helps stabilize the “comfort threshold” around joints, so everyday activities are less likely to be interrupted by recurring discomfort.
Acanthopanacis Cortex
Traditionally associated with supporting tendon and bone strength and overall tolerance, Acanthopanacis Cortex is especially suited for age-related changes or joints that have been used extensively over time and recover more slowly.
Within the Layla formula, it represents a layer of “foundational resilience”: helping joints feel less easily fatigued during prolonged walking, standing, training, or daily chores, and supporting a steadier activity experience.
Achyranthis Radix
In traditional use, Achyranthis Radix is often associated with guiding circulation downward and supporting joint pathways, making it particularly suitable for knee and lower-limb joints that feel tight, swollen, or restricted when climbing stairs or squatting.
Its value in the formula lies in directing flexibility and flow more specifically toward the lower body, helping walking, uphill movement, and stair use feel smoother, and reducing that “hardest moment at the start of movement” sensation.
Clematis hexapetala
Traditionally used for joint support related to sensitivity to wind, cold, or dampness, Clematis hexapetala is often chosen for joints that feel noticeably worse when the weather changes.
In Layla, it plays the role of “freeing joints from heaviness or blockage”: helping reduce resistance during movement and supporting more decisive, fluid joint action—especially during seasonal transitions or cold, humid conditions.
Cinnamon Bark (Cinnamomum cassia)
Cinnamon bark is traditionally used to warm circulation and dispel cold-related stagnation, making it suitable for joints that feel stiffer and tighter in cold conditions and more comfortable when warmed.
Within the formula, cinnamon acts like an “activation switch”: helping joints enter a warmer, more fluid state more easily, easing morning stiffness or stiffness after prolonged sitting, and supporting smoother transitions before and after activity.
Gentianae Macrophyllae Radix
Gentianae Macrophyllae Radix is traditionally used to ease joint soreness and support limited mobility, particularly in “fatigue-type” joint discomfort— joints that feel noticeably sore or heavy after a long day of use.
In Layla’s synergistic blend, it supports the sensation of “carrying fatigue away from the joints,” helping recovery feel steadier after daily load and reducing the likelihood of lingering stiffness the next day.
Cnidium officinale
Traditionally used to promote circulation and ease tightness or dull discomfort, Cnidium officinale is well suited for sensations that are not localized pain, but rather a broad feeling of heaviness, tightness, or congestion around the joints.
Its role in the formula is to help surrounding tissues feel looser and more open: guiding joints away from a “the more you move, the tighter it feels” pattern, and back toward a more comfortable “the more you move, the easier it gets” rhythm.
Gastrodia elata
Gastrodia elata is traditionally associated with calming nervous tension and relaxing connective tissues, making it especially suitable for people experiencing high stress, poor sleep, or muscle tightness that contributes to joint discomfort.
Many joint issues don’t originate solely in the joint itself, but from prolonged tension in surrounding muscles. In Layla, Gastrodia elata supports the release of that tension, helping the body shift out of a constant “tight mode” so joint movement feels easier and smoother.
Safflower (Carthamus tinctorius)
Traditionally used to promote circulation and ease stagnation-type discomfort, safflower is well suited for joints that feel heavy, swollen, or dull, especially after long periods of sitting or standing.
In the synergistic blend, safflower acts as the force that “gets things moving again”: helping joints feel lighter and reducing the buildup of discomfort after walking, standing, or daily activity.
12-Herb Synergistic Blend (3.5:1 Extract)
The core of Layla is not a single “hero ingredient,” but the synergy of 12 herbs working toward the same goal: supporting soft-tissue relaxation, circulation, and inflammatory balance, all designed around how joints are used in real daily life— from standing up and walking to stair climbing and post-training recovery.
Compared with formulas that focus only on supplying raw materials, this blended approach is better suited for joints under long-term load, slower recovery, or hormonal transition phases. Gentle, hormone-free, and not reliant on chemical pain relievers, it is designed as a sustainable, everyday joint management solution.
Excipients & Film Coating (for Everyday Use)
To enhance stability and ease of use, Layla uses a film-coated tablet system with commonly used excipients (such as Opadry coating, magnesium stearate, silicon dioxide, hydroxypropyl cellulose, and related ingredients). This makes the tablets easier to swallow and suitable for long-term, regular use.
If you are sensitive to specific excipients or allergens, it is recommended to review the full ingredient list or consult a professional before purchase to ensure a more comfortable and confident experience.
Who It’s For
-
✔ People who’ve tried glucosamine, chondroitin, and MSM but felt limited results
If you’ve been supplementing G + C + M for a long time yet still feel stiffness or restricted movement, Layla offers an option beyond simply “adding building blocks,” with a stronger focus on real-life joint comfort during everyday use. -
✔ Those who want to reduce reliance on painkillers
For people who don’t want to use non-steroidal pain relievers long term but still want to maintain joint comfort, Layla’s non-steroidal, plant-based, hormone-free profile makes it more suitable to incorporate into long-term lifestyle management. -
✔ Middle-aged and older adults with degenerative joint discomfort
Age-related changes may show up as soreness after long walks, knee strain when climbing stairs, or joints feeling less steady after prolonged standing. Layla’s herbal compound approach places more emphasis on comfort and tolerance under long-term joint use, making it suitable for ongoing daily support. -
✔ Women 40+ / perimenopause and menopause transition
As estrogen levels fluctuate or gradually decline, lubrication, circulation, and recovery capacity around joints may weaken, making morning stiffness, discomfort after sitting, or weather-related sensitivity more likely. Layla is better suited as a hormone-free, long-term option for everyday joint soothing and management support. -
✔ Long-term exercisers / fitness enthusiasts / physical workers
Including runners, strength trainers, yoga practitioners, hikers, and people whose work requires long standing or repetitive movement. When joint concerns are not from acute injury but from “long-term use with slower recovery,” Layla can fit better as a joint support strategy for training recovery and everyday activity.
*Not suitable for children. If you are pregnant or breastfeeding, or if you are taking prescription medications, please consult a healthcare professional before use.
Active Ingredients & Excipients per Tablet
| Ingredient Name | Functional Role | Pharmacopoeia / Quality Standard | Amount per Tablet (mg) |
|---|---|---|---|
| Angelica gigas Chaenomelis Fructus (Chaenomeles Fruit) Saposhnikovia Root Dipsaci Radix Acanthopanax Root Bark Achyranthes Root Clematidis Radix Cinnamon Bark Gentianae Macrophyllae Radix Cnidium Rhizome Gastrodia Rhizome Safflower |
Herbal active ingredients (12-herb synergistic blend) |
In-house | 405.4 |
| Glyceryl Behenate | Diluent / Tableting agent | NF | 8.3 |
| Light Anhydrous Silicic Acid | Diluent | KP | 160 |
| Hydroxypropylcellulose | Binder | JP | 40 |
| Polacrilin Potassium | Disintegrant | NF | 60 |
| Magnesium Stearate | Lubricant | KP | 8.3 |
| Opadry White (OY-C-7000A) | Film coating | In-house | 10 |
| Opadry Yellow (80W42096) | Film coating | In-house | 30 |
*The above represents the composition per tablet. Layla uses a synergistic extract of 12 herbs (approximately a 3.5:1 extraction ratio). The formula is designed to support joint comfort, mobility, and long-term tolerance, is hormone-free, and does not rely on chemical pain-relief agents.
Directions for Use
- Intended users: For adult use only
- Daily dosage: Take 1 tablet per dose, twice daily, with warm water
- Timing: Best taken with meals or after meals to support absorption and be gentler on the stomach
Layla is a herbal joint management formula, not a fast-acting stimulant product. Regular, consistent use is recommended so the 12 herbal ingredients can build stable support in the body, helping improve joint comfort and mobility during everyday activities.
For individuals with long-term joint discomfort or higher activity loads, it is recommended to continue use for at least one full cycle before evaluating results based on personal activity experience and physical sensations.
*If you are taking prescription medications or have specific health conditions, please consult a doctor or qualified professional before use.
About the KInD™ Pro Program
The KInD™ Pro Program is LOLU’s long-term body management framework, focusing on sustainable balance through the integration of nutrition, movement, and recovery. Within this system, Layla is positioned as a foundational support for joint comfort and activity tolerance. Through its 12-herb synergistic formula, it helps ease stiffness and discomfort during daily activities, and is best used alongside dietary optimization, weight management, and low-impact exercise as part of a long-term joint management approach, rather than a short-term solution.
*The KInD™ Pro Program is a lifestyle and nutrition framework. Layla is one of its botanical nutritional support components.
