Aquamin F® (Seaweed Calcium)

Aquamin F® is a multi-mineral complex derived from the red marine algae Lithothamnion calcareum, sustainably harvested from the pristine seabed of the North Atlantic Ocean. What sets Aquamin F® apart from traditional calcium supplements is its naturally porous, honeycomb-like structure that allows for superior bioavailability and gastrointestinal tolerance.

Each capsule provides calcium in its plant-based, ionically bound form along with naturally occurring magnesium and over 70 trace minerals such as boron, strontium, and selenium. These co-factors are essential for proper calcium metabolism and bone mineralization.

Scientific studies have shown that Aquamin F® may help improve bone mineral density, reduce markers of joint inflammation, and enhance cartilage integrity in osteoarthritis models. It has also been clinically studied for its effects on gut barrier function and systemic inflammation, making it a comprehensive support for skeletal and joint health.

Unlike synthetic calcium carbonate or citrate, Aquamin F® is naturally derived, sustainably sourced, and certified organic — ideal for individuals seeking clean-label, plant-based bone support.

Vitamin D3

Vitamin D3 (cholecalciferol) is the active form of vitamin D naturally produced in human skin upon exposure to sunlight. It plays a crucial regulatory role in calcium and phosphate absorption from the intestines, helping maintain healthy levels in the blood that are essential for proper bone mineralization.

Deficiency in vitamin D3 can lead to impaired bone development, increased fracture risk, and compromised immune resilience. In adults, low levels are associated with osteoporosis, muscle weakness, and chronic inflammation. Adequate D3 intake improves calcium bioavailability, reduces bone turnover, and supports immune surveillance functions through modulation of T-cell responses.

In the context of calcium supplementation, vitamin D3 is indispensable—it ensures that dietary or supplemental calcium is absorbed effectively and delivered to where it’s needed: the bones, not the bloodstream or arteries.

Vitamin K1

Vitamin K1 (phylloquinone) is a fat-soluble nutrient primarily responsible for activating blood clotting proteins. Beyond its classic role in coagulation, K1 is also involved in skeletal health through its influence on osteocalcin, a protein that binds calcium to bone matrix.

In bone physiology, vitamin K1 supports the carboxylation of calcium-binding proteins, helping deposit calcium into bones rather than soft tissues. This function is especially important for those taking calcium or vitamin D3 supplements, as improperly regulated calcium can accumulate in the arteries and increase cardiovascular risk.

While less potent than K2 in terms of bone-specific activity, vitamin K1 contributes to the foundational matrix of calcium balance and works alongside other micronutrients to preserve structural integrity and vascular safety.

Vitamin K2 (MK-7)

Vitamin K2, particularly in the MK-7 (menaquinone-7) form, is one of the most crucial yet overlooked cofactors in calcium metabolism. It activates two key proteins: osteocalcin, which integrates calcium into bones, and matrix Gla protein (MGP), which inhibits calcium deposition in arteries and soft tissues.

Unlike vitamin K1, MK-7 remains in circulation much longer (up to 72 hours), allowing it to exert sustained biological effects throughout the vascular and skeletal systems. This extended half-life makes MK-7 especially effective in supporting bone density while preventing arterial calcification—a dual benefit critical for long-term health in aging populations.

When taken in combination with vitamin D3, K2 ensures that absorbed calcium is directed to the skeleton and not left circulating, which could otherwise lead to vascular stiffness. This synergy forms the scientific basis of modern calcium supplementation strategies.